The beauty of a Window 98 registry cleaner is you don’t have to seek out a registry cleaner that is Vista ready or Vista certified.  On the other hand, there are more and more registry cleaners that are not compatible with Windows 98.  In other words, some of the newer ones are compatible with Windows XP [...]

XP registry cleaners are usually made to be compatible with Windows 2000 as well.  This because both Windows XP and Windows 2000 use  NTFS file systems whereas Windows ME, 98 and 95 use FAT32.  However, many of the  registry cleaner program writers make these programs capable of figuring out what operating system it is operating [...]